top of page



Abdullah, M.O., Zeng, R.X., Margerum, C.L., Papadopoli, D., Monnin, C., Punter, K.B., Chu, C., Al-Rofaidi, M., Al-Tannak, N.F., Berardi, D., Rattray, Z., Rattray, N.J.W., Abraham, S.A., Eskelinen, E.L., Watson, D.G., Avizonis, D., Topisirovic, I., and Chan, E.Y.W. (2022). Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids. Cell Rep 40, 111198.




Klionsky, D. J., et al. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17, 1-382.



Grenier-Pleau, I., Tyryshkin, K., Le, T.D., Rudan, J., Bonneil, E., Thibault, P., Zeng, K., Lässer, C., Mallinson, D., Lamprou, D., Hui, J., Postovit, L.M., Chan, E.Y.W. and Abraham, S.A. (2020). Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age. Aging Cell, 19:e13245.


Radhi, O. A., S. Davidson, F. Scott, R. X. Zeng, D. H. Jones, N. C. O. Tomkinson, J. Yu, and E. Y. W. Chan. (2019)  Inhibition of the Ulk1 Protein Complex Suppresses Staphylococcus-Induced Autophagy and Cell Death.  J Biol Chem.

Anwar, T., X. Liu, T. Suntio, A. Marjamaki, J. Biazik, E. Y. W. Chan, M. Varjosalo, and E. L. Eskelinen. (2019)  Er-Targeted Beclin 1 Supports Autophagosome Biogenesis in the Absence of Ulk1 and Ulk2 Kinases.  Cells 8.

Nwadike, C., L. E. Williamson, L. E. Gallagher, J. L. Guan, and E. Y. W. Chan. (2018)  Ampk Inhibits Ulk1-Dependent Autophagosome Formation and Lysosomal Acidification Via Distinct Mechanisms.  Mol Cell Biol 38.

Mitchell, R., L. E. M. Hopcroft, P. Baquero, E. K. Allan, K. Hewit, D. James, G. Hamilton, A. Mukhopadhyay, J. O'Prey, A. Hair, J. V. Melo, E. Chan, K. M. Ryan, V. Maguer-Satta, B. J. Druker, R. E. Clark, S. Mitra, P. Herzyk, F. E. Nicolini, P. Salomoni, E. Shanks, B. Calabretta, T. L. Holyoake, and G. V. Helgason. (2018)  Targeting Bcr-Abl-Independent Tki Resistance in Chronic Myeloid Leukemia by Mtor and Autophagy Inhibition.  J Natl Cancer Inst 110: 467-78.

Gallagher, L. E., O. A. Radhi, M. O. Abdullah, A. G. McCluskey, M. Boyd, and E. Y. W. Chan. (2017)  Lysosomotropism Depends on Glucose: A Chloroquine Resistance Mechanism.  Cell Death Dis 8: e3014.


Karvela, M., P. Baquero, E. M. Kuntz, A. Mukhopadhyay, R. Mitchell, E. K. Allan, E. Chan, K. R. Kranc, B. Calabretta, P. Salomoni, E. Gottlieb, T. L. Holyoake, and G. V. Helgason. (2016)  Atg7 Regulates Energy Metabolism, Differentiation and Survival of Philadelphia-Chromosome-Positive Cells.  Autophagy 12: 936-48.


Gallagher, Laura, Leon Williamson, and Edmond Chan. (2016)  Advances in Autophagy Regulatory Mechanisms.  Cells 5: 24.


Watson, D. G., F. Tonelli, M. Alossaimi, L. Williamson, E. Chan, I. Gorshkova, E. Berdyshev, R. Bittman, N. J. Pyne, and S. Pyne. (2013)  The Roles of Sphingosine Kinases 1 and 2 in Regulating the Warburg Effect in Prostate Cancer Cells.  Cell Signal 25: 1011-7.


Tonelli, F., M. Alossaimi, L. Williamson, R. J. Tate, D. G. Watson, E. Chan, R. Bittman, N. J. Pyne, and S. Pyne. (2013)  The Sphingosine Kinase Inhibitor 2-(P-Hyroxyanilino)-4-(P-Chlorophenyl)Thiazole Reduces Androgen Receptor Expression Via an Oxidative Stress-Dependent Mechanism.  Br J Pharmacol 168: 1497-505.

Mleczak, A., S. Millar, S. A. Tooze, M. F. Olson, and E. Y. Chan. (2013)  Regulation of Autophagosome Formation by Rho Kinase.  Cell Signal 25: 1-11.


McAlpine, F., L. E. Williamson, S. A. Tooze, and E. Y. Chan. (2013)  Regulation of Nutrient-Sensitive Autophagy by Uncoordinated 51-Like Kinases 1 and 2.  Autophagy 9: 361-73.


Gallagher, L. E. and E. Y. Chan. (2013)  Early Signalling Events of Autophagy.  Essays Biochem 55: 1-15.


Chan, E. Y. (2012)  Regulation and Function of Uncoordinated-51 Like Kinase Proteins.  Antioxid Redox Signal 17: 775-85.

Razi, M., E. Y. Chan, and S. A. Tooze. (2009)  Early Endosomes and Endosomal Coatomer Are Required for Autophagy.  J Cell Biol 185: 305-21.



Chan, E. Y. and S. A. Tooze. (2009)  Evolution of Atg1 Function and Regulation.  Autophagy 5: 758-65.



Chan, E. Y., A. Longatti, N. C. McKnight, and S. A. Tooze. (2009)  Kinase-Inactivated Ulk Proteins Inhibit Autophagy Via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism.  Mol Cell Biol 29: 157-71.


Chan, E. Y. (2009)  MTORC1 Phosphorylates the Ulk1-Matg13-Fip200 Autophagy Regulatory Complex.  Sci Signal 2: pe51.



Chan, E. Y., S. Kir, and S. A. Tooze. (2007)  siRNA Screening of the Kinome Identifies Ulk1 as a Multidomain Modulator of Autophagy.  J Biol Chem 282: 25464-74.

Young, A. R., E. Y. Chan, X. W. Hu, R. Kochl, S. G. Crawshaw, S. High, D. W. Hailey, J. Lippincott-Schwartz, and S. A. Tooze. (2006)  Starvation and Ulk1-Dependent Cycling of Mammalian Atg9 between the Tgn and Endosomes. J Cell Sci 119: 3888-900.


Kochl, R., X. W. Hu, E. Y. Chan, and S. A. Tooze. (2006)  Microtubules Facilitate Autophagosome Formation and Fusion of Autophagosomes with Endosomes.  Traffic 7: 129-45.


Warby, S. C., E. Y. Chan, M. Metzler, L. Gan, R. R. Singaraja, S. F. Crocker, H. A. Robertson, and M. R. Hayden. (2005)  Huntingtin Phosphorylation on Serine 421 Is Significantly Reduced in the Striatum and by Polyglutamine Expansion in Vivo.  Hum Mol Genet 14: 1569-77.

Tang, T. S., H. Tu, P. C. Orban, E. Y. Chan, M. R. Hayden, and I. Bezprozvanny. (2004)  Hap1 Facilitates Effects of Mutant Huntingtin on Inositol 1,4,5-Trisphosphate-Induced Ca Release in Primary Culture of Striatal Medium Spiny Neurons.  Eur J Neurosci 20: 1779-87.

Tang, T. S., H. Tu, E. Y. Chan, A. Maximov, Z. Wang, C. L. Wellington, M. R. Hayden, and I. Bezprozvanny. (2003) Huntingtin and Huntingtin-Associated Protein 1 Influence Neuronal Calcium Signaling Mediated by Inositol-(1,4,5) Triphosphate Receptor Type 1.  Neuron 39: 227-39.

Luthi-Carter, R., S. A. Hanson, A. D. Strand, D. A. Bergstrom, W. Chun, N. L. Peters, A. M. Woods, E. Y. Chan, C. Kooperberg, D. Krainc, A. B. Young, S. J. Tapscott, and J. M. Olson. (2002)  Dysregulation of Gene Expression in the R6/2 Model of Polyglutamine Disease: Parallel Changes in Muscle and Brain.  Hum Mol Genet 11: 1911-26.

Chan, E. Y., S. L. Stang, D. A. Bottorff, and J. C. Stone. (2002)  Mutations in Conserved Regions 1, 2, and 3 of Raf-1 That Activate Transforming Activity.  Mol Carcinog 33: 189-97.

Chan, E. Y., J. Nasir, C. A. Gutekunst, S. Coleman, A. Maclean, A. Maas, M. Metzler, M. Gertsenstein, C. A. Ross, A. Nagy, and M. R. Hayden. (2002)  Targeted Disruption of Huntingtin-Associated Protein-1 (Hap1) Results in Postnatal Death Due to Depressed Feeding Behavior.  Hum Mol Genet 11: 945-59.

Chan, E. Y., R. Luthi-Carter, A. Strand, S. M. Solano, S. A. Hanson, M. M. DeJohn, C. Kooperberg, K. O. Chase, M. DiFiglia, A. B. Young, B. R. Leavitt, J. H. Cha, N. Aronin, M. R. Hayden, and J. M. Olson. (2002)  Increased Huntingtin Protein Length Reduces the Number of Polyglutamine-Induced Gene Expression Changes in Mouse Models of Huntington's Disease.  Hum Mol Genet 11: 1939-51.

Chan, E. Y. (2002)  Hip1 as a Marker of Aggressive Prostate Cancer.  Clin Genet 62: 372-5.

Hanna, A. N., E. Y. Chan, J. Xu, J. C. Stone, and D. N. Brindley. (1999)  A Novel Pathway for Tumor Necrosis Factor-Alpha and Ceramide Signaling Involving Sequential Activation of Tyrosine Kinase, P21(Ras), and Phosphatidylinositol 3-Kinase.  J Biol Chem 274: 12722-9.


Chan, E. Y., S. L. Stang, D. A. Bottorff, and J. C. Stone. (1999)  Hypothermic Stress Leads to Activation of Ras-Erk Signaling.  J Clin Invest 103: 1337-44.

Ebinu, J. O., D. A. Bottorff, E. Y. Chan, S. L. Stang, R. J. Dunn, and J. C. Stone. (1998)  RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs.  Science 280: 1082-6.


Rusinol, A. E., E. Y. Chan, and J. E. Vance. (1993)  Movement of Apolipoprotein B into the Lumen of Microsomes from Hepatocytes Is Disrupted in Membranes Enriched in Phosphatidylmonomethylethanolamine.  J Biol Chem 268: 25168-75.

bottom of page