Publications

Abdullah, M.O., Zeng, R.X., Margerum, C.L., Papadopoli, D., Monnin, C., Punter, K.B., Chu, C., Al-Rofaidi, M., Al-Tannak, N.F., Berardi, D., Rattray, Z., Rattray, N.J.W., Abraham, S.A., Eskelinen, E.L., Watson, D.G., Avizonis, D., Topisirovic, I., and Chan, E.Y.W. (2022). Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids. Cell Rep 40, 111198.   https://doi.org/10.1016/j.celrep.2022.111198

 

 

 

Klionsky, D. J., et al. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17, 1-382.   https://doi.org/10.1080/15548627.2020.1797280

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Grenier-Pleau, I., Tyryshkin, K., Le, T.D., Rudan, J., Bonneil, E., Thibault, P., Zeng, K., Lässer, C., Mallinson, D., Lamprou, D., Hui, J., Postovit, L.M., Chan, E.Y.W. and Abraham, S.A. (2020). Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age. Aging Cell, 19:e13245. https://doi.org/10.1111/acel.13245

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Radhi, O. A., S. Davidson, F. Scott, R. X. Zeng, D. H. Jones, N. C. O. Tomkinson, J. Yu, and E. Y. W. Chan. (2019)  Inhibition of the Ulk1 Protein Complex Suppresses Staphylococcus-Induced Autophagy and Cell Death.  J Biol Chem. http://dx.doi.org/10.1074/jbc.RA119.008923.

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Anwar, T., X. Liu, T. Suntio, A. Marjamaki, J. Biazik, E. Y. W. Chan, M. Varjosalo, and E. L. Eskelinen. (2019)  Er-Targeted Beclin 1 Supports Autophagosome Biogenesis in the Absence of Ulk1 and Ulk2 Kinases.  Cells 8. http://dx.doi.org/10.3390/cells8050475.

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Nwadike, C., L. E. Williamson, L. E. Gallagher, J. L. Guan, and E. Y. W. Chan. (2018)  Ampk Inhibits Ulk1-Dependent Autophagosome Formation and Lysosomal Acidification Via Distinct Mechanisms.  Mol Cell Biol 38. http://dx.doi.org/10.1128/MCB.00023-18.

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Mitchell, R., L. E. M. Hopcroft, P. Baquero, E. K. Allan, K. Hewit, D. James, G. Hamilton, A. Mukhopadhyay, J. O'Prey, A. Hair, J. V. Melo, E. Chan, K. M. Ryan, V. Maguer-Satta, B. J. Druker, R. E. Clark, S. Mitra, P. Herzyk, F. E. Nicolini, P. Salomoni, E. Shanks, B. Calabretta, T. L. Holyoake, and G. V. Helgason. (2018)  Targeting Bcr-Abl-Independent Tki Resistance in Chronic Myeloid Leukemia by Mtor and Autophagy Inhibition.  J Natl Cancer Inst 110: 467-78. http://dx.doi.org/10.1093/jnci/djx236.

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Gallagher, L. E., O. A. Radhi, M. O. Abdullah, A. G. McCluskey, M. Boyd, and E. Y. W. Chan. (2017)  Lysosomotropism Depends on Glucose: A Chloroquine Resistance Mechanism.  Cell Death Dis 8: e3014. http://dx.doi.org/10.1038/cddis.2017.416.

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Karvela, M., P. Baquero, E. M. Kuntz, A. Mukhopadhyay, R. Mitchell, E. K. Allan, E. Chan, K. R. Kranc, B. Calabretta, P. Salomoni, E. Gottlieb, T. L. Holyoake, and G. V. Helgason. (2016)  Atg7 Regulates Energy Metabolism, Differentiation and Survival of Philadelphia-Chromosome-Positive Cells.  Autophagy 12: 936-48. http://dx.doi.org/10.1080/15548627.2016.1162359.

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Gallagher, Laura, Leon Williamson, and Edmond Chan. (2016)  Advances in Autophagy Regulatory Mechanisms.  Cells 5: 24. http://dx.doi.org/10.3390/cells5020024.

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Watson, D. G., F. Tonelli, M. Alossaimi, L. Williamson, E. Chan, I. Gorshkova, E. Berdyshev, R. Bittman, N. J. Pyne, and S. Pyne. (2013)  The Roles of Sphingosine Kinases 1 and 2 in Regulating the Warburg Effect in Prostate Cancer Cells.  Cell Signal 25: 1011-7. http://dx.doi.org/10.1016/j.cellsig.2013.01.002.

 

Tonelli, F., M. Alossaimi, L. Williamson, R. J. Tate, D. G. Watson, E. Chan, R. Bittman, N. J. Pyne, and S. Pyne. (2013)  The Sphingosine Kinase Inhibitor 2-(P-Hyroxyanilino)-4-(P-Chlorophenyl)Thiazole Reduces Androgen Receptor Expression Via an Oxidative Stress-Dependent Mechanism.  Br J Pharmacol 168: 1497-505. http://dx.doi.org/10.1111/bph.12035.

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Mleczak, A., S. Millar, S. A. Tooze, M. F. Olson, and E. Y. Chan. (2013)  Regulation of Autophagosome Formation by Rho Kinase.  Cell Signal 25: 1-11. http://dx.doi.org/10.1016/j.cellsig.2012.09.010.

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McAlpine, F., L. E. Williamson, S. A. Tooze, and E. Y. Chan. (2013)  Regulation of Nutrient-Sensitive Autophagy by Uncoordinated 51-Like Kinases 1 and 2.  Autophagy 9: 361-73. http://dx.doi.org/10.4161/auto.23066.

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Gallagher, L. E. and E. Y. Chan. (2013)  Early Signalling Events of Autophagy.  Essays Biochem 55: 1-15. http://dx.doi.org/10.1042/bse0550001.

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Chan, E. Y. (2012)  Regulation and Function of Uncoordinated-51 Like Kinase Proteins.  Antioxid Redox Signal 17: 775-85. http://dx.doi.org/10.1089/ars.2011.4396.

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Razi, M., E. Y. Chan, and S. A. Tooze. (2009)  Early Endosomes and Endosomal Coatomer Are Required for Autophagy.  J Cell Biol 185: 305-21. http://dx.doi.org/10.1083/jcb.200810098.

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Chan, E. Y. and S. A. Tooze. (2009)  Evolution of Atg1 Function and Regulation.  Autophagy 5: 758-65. https://doi.org/10.4161/auto.8709.

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Chan, E. Y., A. Longatti, N. C. McKnight, and S. A. Tooze. (2009)  Kinase-Inactivated Ulk Proteins Inhibit Autophagy Via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism.  Mol Cell Biol 29: 157-71. http://dx.doi.org/10.1128/MCB.01082-08.

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Chan, E. Y. (2009)  MTORC1 Phosphorylates the Ulk1-Matg13-Fip200 Autophagy Regulatory Complex.  Sci Signal 2: pe51. http://dx.doi.org/10.1126/scisignal.284pe51.

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Chan, E. Y., S. Kir, and S. A. Tooze. (2007)  siRNA Screening of the Kinome Identifies Ulk1 as a Multidomain Modulator of Autophagy.  J Biol Chem 282: 25464-74. http://dx.doi.org/10.1074/jbc.M703663200.

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Young, A. R., E. Y. Chan, X. W. Hu, R. Kochl, S. G. Crawshaw, S. High, D. W. Hailey, J. Lippincott-Schwartz, and S. A. Tooze. (2006)  Starvation and Ulk1-Dependent Cycling of Mammalian Atg9 between the Tgn and Endosomes. J Cell Sci 119: 3888-900. http://dx.doi.org/10.1242/jcs.03172.

 

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Kochl, R., X. W. Hu, E. Y. Chan, and S. A. Tooze. (2006)  Microtubules Facilitate Autophagosome Formation and Fusion of Autophagosomes with Endosomes.  Traffic 7: 129-45. http://dx.doi.org/10.1111/j.1600-0854.2005.00368.x.

 

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Warby, S. C., E. Y. Chan, M. Metzler, L. Gan, R. R. Singaraja, S. F. Crocker, H. A. Robertson, and M. R. Hayden. (2005)  Huntingtin Phosphorylation on Serine 421 Is Significantly Reduced in the Striatum and by Polyglutamine Expansion in Vivo.  Hum Mol Genet 14: 1569-77. http://dx.doi.org/10.1093/hmg/ddi165.

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Tang, T. S., H. Tu, P. C. Orban, E. Y. Chan, M. R. Hayden, and I. Bezprozvanny. (2004)  Hap1 Facilitates Effects of Mutant Huntingtin on Inositol 1,4,5-Trisphosphate-Induced Ca Release in Primary Culture of Striatal Medium Spiny Neurons.  Eur J Neurosci 20: 1779-87. http://dx.doi.org/10.1111/j.1460-9568.2004.03633.x.

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Tang, T. S., H. Tu, E. Y. Chan, A. Maximov, Z. Wang, C. L. Wellington, M. R. Hayden, and I. Bezprozvanny. (2003) Huntingtin and Huntingtin-Associated Protein 1 Influence Neuronal Calcium Signaling Mediated by Inositol-(1,4,5) Triphosphate Receptor Type 1.  Neuron 39: 227-39.  https://doi.org/10.1016/S0896-6273(03)00366-0.

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Luthi-Carter, R., S. A. Hanson, A. D. Strand, D. A. Bergstrom, W. Chun, N. L. Peters, A. M. Woods, E. Y. Chan, C. Kooperberg, D. Krainc, A. B. Young, S. J. Tapscott, and J. M. Olson. (2002)  Dysregulation of Gene Expression in the R6/2 Model of Polyglutamine Disease: Parallel Changes in Muscle and Brain.  Hum Mol Genet 11: 1911-26. https://doi.org/10.1093/hmg/11.17.1911.

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Chan, E. Y., S. L. Stang, D. A. Bottorff, and J. C. Stone. (2002)  Mutations in Conserved Regions 1, 2, and 3 of Raf-1 That Activate Transforming Activity.  Mol Carcinog 33: 189-97. https://doi.org/10.1002/mc.10031.

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Chan, E. Y., J. Nasir, C. A. Gutekunst, S. Coleman, A. Maclean, A. Maas, M. Metzler, M. Gertsenstein, C. A. Ross, A. Nagy, and M. R. Hayden. (2002)  Targeted Disruption of Huntingtin-Associated Protein-1 (Hap1) Results in Postnatal Death Due to Depressed Feeding Behavior.  Hum Mol Genet 11: 945-59.  https://doi.org/10.1093/hmg/11.8.945.

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Chan, E. Y., R. Luthi-Carter, A. Strand, S. M. Solano, S. A. Hanson, M. M. DeJohn, C. Kooperberg, K. O. Chase, M. DiFiglia, A. B. Young, B. R. Leavitt, J. H. Cha, N. Aronin, M. R. Hayden, and J. M. Olson. (2002)  Increased Huntingtin Protein Length Reduces the Number of Polyglutamine-Induced Gene Expression Changes in Mouse Models of Huntington's Disease.  Hum Mol Genet 11: 1939-51. https://doi.org/10.1093/hmg/11.17.1939.

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Chan, E. Y. (2002)  Hip1 as a Marker of Aggressive Prostate Cancer.  Clin Genet 62: 372-5. http://dx.doi.org/10.1034/j.1399-0004.2002.620503_4.x.

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Hanna, A. N., E. Y. Chan, J. Xu, J. C. Stone, and D. N. Brindley. (1999)  A Novel Pathway for Tumor Necrosis Factor-Alpha and Ceramide Signaling Involving Sequential Activation of Tyrosine Kinase, P21(Ras), and Phosphatidylinositol 3-Kinase.  J Biol Chem 274: 12722-9. https://doi.org/10.1074/jbc.274.18.12722.

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Chan, E. Y., S. L. Stang, D. A. Bottorff, and J. C. Stone. (1999)  Hypothermic Stress Leads to Activation of Ras-Erk Signaling.  J Clin Invest 103: 1337-44. http://dx.doi.org/10.1172/jci5474.

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Ebinu, J. O., D. A. Bottorff, E. Y. Chan, S. L. Stang, R. J. Dunn, and J. C. Stone. (1998)  RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs.  Science 280: 1082-6. https://doi.org/10.1126/science.280.5366.1082.

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Rusinol, A. E., E. Y. Chan, and J. E. Vance. (1993)  Movement of Apolipoprotein B into the Lumen of Microsomes from Hepatocytes Is Disrupted in Membranes Enriched in Phosphatidylmonomethylethanolamine.  J Biol Chem 268: 25168-75. https://doi.org/10.1016/S0021-9258(19)74584-0.